Regulation of transferrin receptor synthesis by human cytotrophoblast cells in culture
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چکیده
منابع مشابه
Regulation of transferrin receptor synthesis by human cytotrophoblast cells in culture.
The aim of this study was to examine the capacity of the syncytiotrophoblast to regulate transferrin receptor (TfR) synthesis in response to modulations in maternal iron supply. The model used was the primary trophoblast cell culture. Trophoblast cells isolated from term human placentas were cultured in iron-poor (Medium 199), iron-depleted (desferrioxamine (DFO)) and iron-supplemented (diferri...
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Treatment of K562 cells with the iron chelator desferrioxamine results in the gradual increase in total cell receptors for transferrin. Receptor number rises 2.5-4.5-fold over 24 h and remains at the elevated level if the chelator is continuously present. Preincubation of the chelator with ferric chloride abolishes the effect. The drug has no effect on the 7-h half-life of the receptor. The inc...
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Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo. HepG2 cell TfR2 protein levels were up-regulated after exposure to holotransferrin (holoTf) in a timeand dose-responsive manner...
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ژورنال
عنوان ژورنال: European Journal of Obstetrics & Gynecology and Reproductive Biology
سال: 1996
ISSN: 0301-2115
DOI: 10.1016/0301-2115(95)02368-2